The recently released version of UpToDate (15.1) contains more than 5000 updates and adds evidence-based grading to many additional treatment and screening recommendations.
The grading system, introduced in February 2006, reflects the strength of the recommendation and the quality of the evidence. Recommendations are based on the clinical expertise of UpToDate authors, editors and peer reviewers. Grades are made up of two components: a number (1 or 2) reflecting a strong or weak recommendation, and a letter (A, B, or C) reflecting the quality of the evidence supporting that recommendation. They are found in the Summary and Recommendations section at the end of graded topics as seen below.
Additional information is contained in the UTD GRADE System web page.